Cancer Heterogeneity and Plasticity

ISSN 2818-7792
Free Publication in 2026

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About This Journal
Cancer Heterogeneity and Plasticity (ISSN 2818-7792) is an international, peer-reviewed, Open Access (OA) journal published quarterly by Pivot Science Publications. It is dedicated to showcasing outstanding original research articles, reviews, and perspectives spanning the dynamic realm of cancer cell heterogeneity and adaptability and the complexities within their microenvironments. Its scope encompasses a wide spectrum of topics, including but not limited to the elucidation of evolutionary relationship of cancer cell subpopulations (i.e., heterogeneity), molecular mechanisms driving cancer cell plasticity (e.g., epithelial-mesenchymal transition or EMT), epigenetic underpinnings of cancer cell reprogramming (e.g., treatment-induced neuroendocrine (NE) transdifferentiation), and the influence of the tumor microenvironment (TME) on cancer cell dynamics. It extends to embrace studies exploring the impact of the microenvironment and systemic host factors (e.g., hormones, growth factors, inflammatory cytokines, and nerves) on cancer progression, therapeutic resistance, cancer cell dissemination and dormancy, metastasis, and the development of innovative targeted and combinatorial therapies.
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About Editor-in-Chief
Dean G. Tang

Distinguished Professor and Chair, Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center (RPCCC), USA

Dean Tang, PhD, is currently Distinguished Professor and Chair of Department of Pharmacology & Therapeutics at the Roswell Park Comprehensive Cancer Center in Buffalo, NY. He also holds the George Decker Endowed Chair in Developmental Therapeutics. Trained as a Pathologist, Dr. Tang obtained his PhD in Cancer Biology in 1994 from Wayne State University (Detroit, MI, USA). In 1998-2000, Dean pursued a Burroughs-Wellcome senior post-doctoral fellowship with Dr. Martin Raff at the MRC LMCB (University College London, UK) studying stem/progenitor cell development and plasticity. In June 2000, Dr. Tang joined the University of Texas M.D Anderson Cancer Center as a faculty member. After working at the M.D Anderson for 16 years, Dr. Tang was recruited to Roswell Park in June of 2016 to Chair the Department of Pharmacology & Therapeutics and Co-Lead the CCSG Developmental Therapeutic (DT) Program. He’s also the Chair of the Experimental Therapeutic (ET) Graduate Program. 
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Latest Articles
Commentary

Rewiring transcriptional plasticity: the case for dual YAP1 and TAZ targeting in gastric cancer peritoneal metastases

Rahul Kumar

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2603010004

Received: Mar 18, 2026 | Accepted: Mar 18, 2026 | Published: Mar 28, 2026
Original Research

YAP1 depletion enhances TAZ and its complexation with TEAD4 and AP-1 heterodimer C-JUN/FOSB in gastric cancer progression and metastasis

Jingjing Wu, Dipti Athavale, Curt Balch, Junsong Zhao, Gengyi Zou, Yibo Fan, Yanting Zhang, Joseph Zhao, Mikel Ghelfi, Anthony Pompetti, Gennaro Calendo, Ailing Scott, Shan Shao, Xiaodan Yao, Melissa Pool Pizzi, Christopher Vellano, Vladimir Khazak, Sheng Zhang, Timothy A Yap, Shilpa S Dhar, Raghav Sundar, Francis Spitz, Generosa Grana, Jaffer A. Ajani, Shumei Song

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2603010003

Received: Jan 16, 2026 | Accepted: Mar 17, 2026 | Published: Mar 28, 2026
Review

Molecular heterogeneity of HPV-associated cancers and strategies to overcome treatment resistance

Sara Rasouli, Weiyi Gong, Raegan Wood, Danyal Daneshdoust, Anam Khan, Rani Mahyoob, Chongwen Cao, Zihao Yu, Nagireddy Putluri, Gennady Shvets, Haichang Li, Bo Zhao, Xuefeng Liu, Jenny Li

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2603010002

Received: Jul 23, 2025 | Accepted: Feb 9, 2026 | Published: Mar 1, 2026
Review

The Trojan Horse Within: Mechanisms of Immune Evasion in Breast Cancer

Biswajit Das, Charles W. Winterbottom, Shaheen S. Sikandar

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2603010001

Received: Aug 5, 2025 | Accepted: Nov 13, 2025 | Published: Dec 5, 2025
Editorial

Acknowledgement to Reviewers of Cancer Heterogeneity and Plasticity in 2025

CHP Editorial Office

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2502040019

Received: Dec 4, 2025 | Accepted: Dec 4, 2025 | Published: Dec 4, 2025
Conference Report

Advancing Cancer Biology: Highlights from the 2025 FASEB SRC on Cellular Plasticity in Cancer

Hans Clevers, Ankur Sharma, Sendurai A. Mani, Anna Golebiewska, Axel Behrens, Wai Leong Tam, Loic P. Deleyrolle, Huiping Liu, Karuna Ganesh, Walid T. Khaled, Shaheen Sikandar, Terence K. Lee, Tyler E. Miller, Dean G. Tang, Sheila Singh, Vivian S.W. Li, Justin D. Lathia, Stephanie Ma

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2502040018

Received: Oct 3, 2025 | Accepted: Oct 3, 2025 | Published: Oct 17, 2025
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