Cancer Heterogeneity and Plasticity

ISSN 2818-7792
Free Publication in 2024

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About This Journal
Cancer Heterogeneity and Plasticity (ISSN 2818-7792) is an international, peer-reviewed, Open Access (OA) journal dedicated to showcasing outstanding original research articles, reviews, and perspectives spanning the dynamic realm of cancer cell heterogeneity and adaptability and the complexities within their microenvironments. Its scope encompasses a wide spectrum of topics, including but not limited to the elucidation of evolutionary relationship of cancer cell subpopulations (i.e., heterogeneity), molecular mechanisms driving cancer cell plasticity (e.g., epithelial-mesenchymal transition or EMT), epigenetic underpinnings of cancer cell reprogramming (e.g., treatment-induced neuroendocrine (NE) transdifferentiation), and the influence of the tumor microenvironment (TME) on cancer cell dynamics. It extends to embrace studies exploring the impact of the microenvironment and systemic host factors (e.g., hormones, growth factors, inflammatory cytokines, and nerves) on cancer progression, therapeutic resistance, cancer cell dissemination and dormancy, metastasis, and the development of innovative targeted and combinatorial therapies.
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About Editor-in-Chief
Dean G. Tang

Professor and Chair, Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center (RPCCC), USA

Dean G. Tang is currently Professor and Chair of Department of Pharmacology & Therapeutics at the Roswell Park Comprehensive Cancer Center in Buffalo, NY. He also holds the George Decker Endowed Chair in Developmental Therapeutics. Trained as a Pathologist, Dr. Tang obtained his PhD in Cancer Biology in 1994 from Wayne State University (Detroit, MI, USA). In 1998-2000, Dean pursued a Burroughs-Wellcome senior post-doctoral fellowship with Dr. Martin Raff at the MRC LMCB (University College London, UK) studying stem/progenitor cell development and plasticity. In June 2000, Dr. Tang joined the University of Texas M.D Anderson Cancer Center as a faculty member. After working at the M.D Anderson for 16 years, Dr. Tang was recruited to Roswell Park in June of 2016 to Chair the Department of Pharmacology & Therapeutics and Co-Lead the CCSG Developmental Therapeutic (DT) Program. He's also the Chair of the Experimental Therapeutic (ET) Graduate Program.
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Latest Articles
Review

Heterogeneity of tumor biophysical properties and their potential role as prognostic markers

Anja Madleine Markl, Daniel Nieder, Diana Isabel Sandoval-Bojorquez, Anna Taubenberger, Jean-Fran?ois Berret, Artur Yakimovich, Eduardo Sergio Oliveros-Mata, Larysa Baraban, Anna Dubrovska

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2401020011

Received: Oct 15, 2024 | Accepted: Nov 28, 2024 | Published: Dec 19, 2024
Review

The molecular determinants of phenotypic plasticity in homeostasis and neoplasia

Bradley Balk, David W. Goodrich

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2401020010

Received: Oct 10, 2024 | Accepted: Nov 14, 2024 | Published: Dec 13, 2024
Commentary

Transcription factor AP-4 (TFAP4) unleashes telomerase reverse transcriptase (TERT) activity in non-viral-associated liver cancers

Paige Eversole, Sayan Chakraborty

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2401020009

Received: Nov 27, 2024 | Accepted: Nov 27, 2024 | Published: Dec 2, 2024
Original Research

Transcription factor AP-4 reactivates telomerase reverse transcriptase independently of genome alteration in non-HBV associated hepatocellular carcinoma

Huiju Lim, Trevor Kwan-Hung Wu, Eliana Mary Senires Suarez, Tiffany Ching-Yun Yu, Joyce Man-Fong Lee, Yu-Man Tsui, Daniel Wai-Hung Ho, Karen Man-Fong Sze, Irene Oi-Lin Ng

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2401020008

Received: Sep 6, 2024 | Accepted: Nov 21, 2024 | Published: Nov 26, 2024
Review

Function of noncoding RNA in regulating cancer cell plasticity

Peter Hyunwuk Her, Magnus Lam, Sarah Zeng, Housheng Hansen He

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2401020007

Received: Aug 28, 2024 | Accepted: Oct 22, 2024 | Published: Nov 12, 2024
Perspective

Developing a novel therapeutic strategy against cancer stem cell heterogeneity and plasticity

Toru Kondo

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2401010006

Received: Jul 11, 2024 | Accepted: Sep 16, 2024 | Published: Sep 27, 2024
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