DIAPH3 in Cancer: Role and Mechanism

Cancer Heterogeneity and Plasticity 2025;2(1):0003 | https://doi.org/10.47248/chp2502010003

Review Open Access

DIAPH3 in Cancer: Role and Mechanism

Jiangling Xiong ^1,2,† , Lanxin Hu ^1,† , Jinwei Zhu ¹ , Lianlian Yan ¹ , Yuqing Feng ¹ , Cheng Zou ¹ , Yang Mei ¹ , Dinglan Wu ³ , Dingxiao Zhang ^1,2

1. Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University, Changsha 410082, Hunan, China
2. Shenzhen Research Institute, Hunan University, Shenzhen 518000, China
3. Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong, China

† These authors contributed equally to this work.

Correspondence: Yang Mei; Dinglan Wu; Dingxiao Zhang

Academic Editor(s): Anna Dubrovska

Received: Dec 6, 2024 | Accepted: Feb 15, 2025 | Published: Feb 25, 2025

Cite this article: Xiong J, Hu L, Zhu J, Yan L, Feng Y, Zou C, Mei Y, Wu D, Zhang D. DIAPH3 in Cancer: Role and Mechanism. Cancer Heterog Plast 2025; 2(1):0003. https://doi.org/10.47248/chp2502010003

Abstract

Diaphanous-related formin 3 (DIAPH3) is a pivotal member of the formin family and serves as a crucial regulator of actin filament assembly. As such, DIAPH3 plays an integral role in a variety of cellular processes including cytokinesis, cell migration, and intracellular transport. Given its fundamental importance in maintaining cytoskeletal dynamics, DIAPH3 is functionally associated with numerous physiological and pathological conditions, particularly cancer. In this review, we explore the structural and functional characteristics of DIAPH3 and investigate its mutational and transcriptional landscape in human cancers. By focusing on DIAPH3’s role in controlling metastasis and tumor microenvironment, we aim to provide new insights into how DIAPH3 contributes to tumor development and progression. Altogether, we believe that an enhanced understanding of the DIAPH3 signalosome will facilitate more precise clinical decision-making and the development of novel therapeutics against aggressive cancers.

Keywords

DIAPH3, Actin nucleation factor, PCa metastasis, Therapeutic targeting

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